Sixto Leal, MD, PhD

Unlike most invasive mold infections, COVID Associated Pulmonary Aspergillosis (CAPA) occurs in individuals with otherwise intact immune systems. This suggests novel biological mechanisms make people susceptible to fungal infection. We seek to evaluate whether immune responses targeting intracellular viruses (viruses that live inside host cells) compromise the ability of the immune system to simultaneously control mold infection. First, we will determine how SARS-CoV-2 (the virus that causes COVID-19) renders people with normal immune systems susceptible to mold infection. Second, we will use a novel mouse model of CAPA to study how SARS-CoV-2 infection kills lung cells, recruits less immune cells, and promotes mold growth. We will also evaluate the utility of novel drugs to prevent the establishment of secondary mold infection. Our overall goal is to better understand why these infections occur in order to prevent their development in patients with an emerging viral respiratory infection.