Yashoda Madaiah Hosakote, PhD

The ongoing devastating COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in overwhelming number of deaths worldwide and still rising. New variants of the virus continue to emerge, such as the recent Delta, Omicron and now its subvariants, which have crippled the world’s economy and weakened healthcare systems. SARS-CoV-2 infection induces an unwanted inflammatory response that can lead to lethal outcomes of COVID-19 disease. We have identified a protein called high mobility group box 1 (HMGB1), which alerts the immune system of potential damage that can be inflicted during SARS-CoV-2 infection. We will investigate the role of HMGB1 in SARS-CoV-2 infection, which may guide us on the development of novel therapeutic strategies to mitigate the COVID-19 pandemic.