Research Project: Role of Tumor Suppressor Protein in Pulmonary Fibrosis
Grant Awarded:
Biomedical Research Grant
Research Topic:
basic biologic mechanisms
Research Disease:
pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating disease associated with progressive and irreversible destruction of the lung architecture. The cause of IPF remains largely unknown even as the annual incidence of IPF is rising. It has been suggested that patients with IPF express increased levels of a certain tumor suppressor protein [VHL] in centers of scarring. This research will attempt to address the regulation of VHL and the causal role of VHL in pulmonary fibrosis.