Kurt Prins, M.D., Ph.D.

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Kurt Prins, MD, PhD

Research Project:
Treating Right Heart Dysfunction to Improve Outcomes in PAH

Grant Awarded:

Innovation Award

Research Topics:

basic biologic mechanisms
combination therapies experimental therapeutics

Research Disease:

pulmonary vascular disease

We have shown small molecule inhibition of WNK1 signaling prevents metabolic derangements in the monocrotaline model of pulmonary arterial hypertension. In particular, we showed WNK1 inhibition prevented pathological increase in glucose uptake, activated AMP kinase signaling, which then manifested as augmented fatty acid metabolism. Importantly, these data suggest that WNK1 may be a target for RV dysfunction in pulmonary arterial hypertension, a currently untreatable consequence of pulmonary arterial hypertension.

Update: We have shown small molecule inhibition of WNK1 enhances RV metabolism and augments RV function in rodent pulmonary arterial hypertension.

Page last updated: June 7, 2024

Kurt Prins, MD, PhD

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